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SS22 WS22 SS23 WS23 SS24 WS24 Guidelines for Master Students
Understanding polymorph selection in nabumentone thin films at surfaces Polymorphs have a strong influence on many different properties including thermodynamic and chemical stability, processibility or dissolution which is turn directly impact pharmaceutical formulation and therapeutic actions. As such the preparation of specific polymorphs as well as their reproducibility is of crucial importance. In this work the polymorphic phase behaviour of nabumetone is studied. This model substance is a non-steroidal anti- inflammatory drug which has two known polymorphs. By employing various thin film fabrication techniques like spin coating, drop casting or dip coating homogenous layers form at substrate surfaces. Nabumetone was dissolved in different solutions like ethanol, toluene and tetrahydrofuran (THF) at different amounts. For sake of increase of surface area, nabumetone is processed together with a matrix forming substance, polystyrene. The thin film properties were examined using microscopy and X-ray diffraction. |